Ser338
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Home > Phosphorylation Site Page: > Ser338  -  Rhodopsin (mouse)

Site Information
DDAsATAsKtEtsQV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448679

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 4 , 5 ) , mutation of modification site ( 6 ) , phospho-antibody ( 2 , 6 ) , western blotting ( 2 , 6 )
Relevant cell line - cell type - tissue:
placental-retina ( 2 ) , retina ( 1 , 4 , 5 , 6 ) , retina [RPE65 (mouse)] ( 3 )

Upstream Regulation
Putative in vivo kinases:
GRK1 (mouse) ( 2 )
Kinases, in vitro:
GRK1 (mouse) ( 2 ) , PKCA (mouse) ( 2 )
Putative upstream phosphatases:
PPP2CA (mouse) ( 1 )
Treatments:
11-cis-retinal ( 3 ) , light ( 1 , 2 , 4 , 5 , 6 ) , phorbol_ester ( 2 )

Downstream Regulation
Effects of modification on Rhodopsin:
receptor inactivation, altered ( 6 )

References 

1

Kolesnikov AV, et al. (2017) Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A 114, E9675-E9684
29078372   Curated Info

2

Adams RA, Liu X, Williams DS, Newton AC (2003) Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. Biochem J 374, 537-43
12809555   Curated Info

3

Ablonczy Z, et al. (2002) 11-cis-retinal reduces constitutive opsin phosphorylation and improves quantum catch in retinoid-deficient mouse rod photoreceptors. J Biol Chem 277, 40491-8
12176991   Curated Info

4

Lee KA, Craven KB, Niemi GA, Hurley JB (2002) Mass spectrometric analysis of the kinetics of in vivo rhodopsin phosphorylation. Protein Sci 11, 862-74
11910029   Curated Info

5

Kennedy MJ, et al. (2001) Multiple phosphorylation of rhodopsin and the in vivo chemistry underlying rod photoreceptor dark adaptation. Neuron 31, 87-101
11498053   Curated Info

6

Mendez A, et al. (2000) Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites. Neuron 28, 153-64
11086991   Curated Info