Ser334
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Home > Phosphorylation Site Page: > Ser334  -  Rhodopsin (mouse)

Site Information
PLGDDDAsATAsKtE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448677

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 ) , mutation of modification site ( 5 ) , phospho-antibody ( 1 , 5 ) , western blotting ( 1 , 5 )
Relevant cell line - cell type - tissue:
placental-retina ( 1 ) , retina ( 3 , 4 , 5 ) , retina [RPE65 (mouse)] ( 2 )

Upstream Regulation
Kinases, in vitro:
PKCA (mouse) ( 1 )
Treatments:
11-cis-retinal ( 2 ) , light ( 1 , 3 , 4 , 5 ) , phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on Rhodopsin:
receptor inactivation, altered ( 5 )

References 

1

Adams RA, Liu X, Williams DS, Newton AC (2003) Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. Biochem J 374, 537-43
12809555   Curated Info

2

Ablonczy Z, et al. (2002) 11-cis-retinal reduces constitutive opsin phosphorylation and improves quantum catch in retinoid-deficient mouse rod photoreceptors. J Biol Chem 277, 40491-8
12176991   Curated Info

3

Lee KA, Craven KB, Niemi GA, Hurley JB (2002) Mass spectrometric analysis of the kinetics of in vivo rhodopsin phosphorylation. Protein Sci 11, 862-74
11910029   Curated Info

4

Kennedy MJ, et al. (2001) Multiple phosphorylation of rhodopsin and the in vivo chemistry underlying rod photoreceptor dark adaptation. Neuron 31, 87-101
11498053   Curated Info

5

Mendez A, et al. (2000) Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites. Neuron 28, 153-64
11086991   Curated Info