Thr641
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Home > Phosphorylation Site Page: > Thr641  -  PKCB iso2 (rat)

Site Information
tRHPPVLtPPDQEVI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1869073010

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 5 , 7 ) , peptide sequencing ( 7 ) , phospho-antibody ( 4 , 6 ) , western blotting ( 4 , 6 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 1 ) , 'brain, cerebellum' ( 1 ) , 'brain, cerebral cortex' ( 1 ) , 'brain, hippocampus' ( 6 ) , 'kidney, cortex' ( 2 ) , adipose tissue ( 1 ) , blood ( 1 ) , brain ( 5 ) , heart ( 4 ) , intestine ( 1 ) , kidney ( 1 ) , liver ( 1 , 3 ) , lung ( 1 ) , Sf21 ( 7 ) , SF9 ( 7 ) , spleen ( 1 ) , stomach ( 1 ) , testis ( 1 ) , thymus ( 1 )

Upstream Regulation
Treatments:
electrical_stimulation ( 6 ) , streptozotocin ( 4 )

References 

1

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

2

Feric M, et al. (2011) Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule. Am J Physiol Cell Physiol 300, C755-70
21209370   Curated Info

3

Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729
21738781   Curated Info

4

Lin G, Liu Y, MacLeod KM (2009) Regulation of muscle creatine kinase by phosphorylation in normal and diabetic hearts. Cell Mol Life Sci 66, 135-44
18979206   Curated Info

5

Guo A (2007) CST Curation Set: 2239; Year: 2007; Biosample/Treatment: tissue, brain/ischemia 20'; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851
Curated Info

6

Thiels E, et al. (2000) Protein phosphatase-mediated regulation of protein kinase C during long-term depression in the adult hippocampus in vivo. J Neurosci 20, 7199-207
11007876   Curated Info

7

Tsutakawa SE, et al. (1995) Determination of in vivo phosphorylation sites in protein kinase C. J Biol Chem 270, 26807-12
7592921   Curated Info