Tyr701
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Home > Phosphorylation Site Page: > Tyr701  -  STAT1 (rat)

Site Information
DDPKRTGyIKTELIS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447754

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 7 ) , mutation of modification site ( 13 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ) , western blotting ( 3 , 5 , 10 , 11 , 12 , 13 , 14 , 15 )
Disease tissue studied:
liver cancer ( 11 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 10 ) , 'muscle, skeletal' ( 9 ) , 'neuron, cerebellar granule'-brain ( 8 ) , astrocyte-'brain, striatum' ( 5 ) , FRTL-5 (thyroid cell) ( 12 , 15 ) , granulosa ( 14 ) , H4IIe (hepatic) ( 11 ) , heart ( 3 ) , hepatocyte-liver ( 7 ) , HIT (pancreatic) ( 6 ) , liver ( 9 ) , myocyte-heart ( 4 , 13 ) , RAEC (endothelial) ( 2 ) , RIN (epithelial) ( 6 ) , U3A (fibroblast) ( 13 )

Upstream Regulation
Regulatory protein:
LEPR (mouse) ( 6 ) , SOCS1 (mouse) ( 15 ) , SOCS3 (mouse) ( 15 )
Treatments:
AG490 ( 5 , 7 , 10 ) , colforsin ( 15 ) , fludarabine ( 7 ) , G-CSF ( 4 ) , ganglioside ( 10 ) , GH ( 6 , 9 ) , H2O2 ( 5 , 12 ) , hypoxia/reoxygenation ( 7 ) , IFN-gamma ( 3 , 5 , 12 , 15 ) , IL-10 ( 5 ) , IL-22 ( 11 ) , IL-6 ( 5 , 6 ) , ischemia/reperfusion ( 3 , 8 ) , leptin ( 6 ) , methimazole ( 12 ) , NAC ( 7 ) , oxysterol ( 2 ) , pregnancy ( 14 ) , PRL ( 14 ) , rottlerin ( 14 ) , sepsis ( 9 ) , tempol ( 3 ) , TSH ( 15 )

Downstream Regulation
Effects of modification on STAT1:
activity, induced ( 7 )
Effects of modification on biological processes:
apoptosis, inhibited ( 7 ) , transcription, altered ( 7 , 13 )

References 

1

Sandoval-Usme MC, et al. (2014) Simvastatin impairs growth hormone-activated signal transducer and activator of transcription (STAT) signaling pathway in UMR-106 osteosarcoma cells. PLoS One 9, e87769
24489959   Curated Info

2

Romeo GR, Kazlauskas A (2008) Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J Biol Chem 283, 9595-605
18230613   Curated Info

3

McCormick J, et al. (2006) Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury. FASEB J 20, 2115-7
16935931   Curated Info

4

Harada M, et al. (2005) G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 11, 305-11
15723072   Curated Info

5

Gorina R, Petegnief V, Chamorro A, Planas AM (2005) AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway. J Neurochem 92, 505-18
15659221   Curated Info

6

Hekerman P, et al. (2005) Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. FEBS J 272, 109-19
15634336   Curated Info

7

Terui K, et al. (2004) Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction. Biochem J 380, 203-9
14984365   Curated Info

8

West DA, et al. (2004) MR image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischemia. Neuroscience 127, 333-9
15262323   Curated Info

9

Hong-Brown LQ, et al. (2003) Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Am J Physiol Endocrinol Metab 285, E63-72
12644450   Curated Info

10

Kim OS, Park EJ, Joe EH, Jou I (2002) JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. J Biol Chem 277, 40594-601
12191995   Curated Info

11

Lejeune D, et al. (2002) Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. J Biol Chem 277, 33676-82
12087100   Curated Info

12

Kim H, et al. (2001) Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging. Mol Pharmacol 60, 972-80
11641425   Curated Info

13

Stephanou A, et al. (2001) Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701. J Biol Chem 276, 28340-7
11309387   Curated Info

14

Peters CA, et al. (2000) Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling. Mol Endocrinol 14, 576-90
10770494   Curated Info

15

Park ES, et al. (2000) Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells. Mol Endocrinol 14, 440-8
10707961   Curated Info