Thr352
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Home > O-GlcNAc Site Page: > Thr352  -  NFkB-p65 (human)

Site Information
APQPYPFtSSLSTIN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 5148301

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , MEF (fibroblast) ( 2 )

Downstream Regulation
Effects of modification on NFkB-p65:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
transcription, induced ( 2 )
Induce interaction with:
DNA ( 2 )

References 

1

Ma Z, Chalkley RJ, Vosseller K (2017) Hyper-O-GlcNAcylation activates nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) signaling through interplay with phosphorylation and acetylation. J Biol Chem 292, 9150-9163
28416608   Curated Info

2

Yang YR, et al. (2015) Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling. Oncotarget 6, 12529-42
25915426   Curated Info

3

Yang WH, et al. (2008) NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions. Proc Natl Acad Sci U S A 105, 17345-50
18988733   Curated Info