Tyr381
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Home > Phosphorylation Site Page: > Tyr381  -  PAG (rat)

Site Information
GEEPEPDyEAIQTLN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 463949

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , microscopy-colocalization with upstream kinase ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 1 , 3 ) , J2E (erythroblast) ( 3 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Putative in vivo kinases:
LYN (mouse) ( 1 , 3 )

Downstream Regulation
Effects of modification on PAG:
intracellular localization ( 1 )
Effects of modification on biological processes:
cell growth, altered ( 2 ) , cytoskeletal reorganization ( 1 )

References 

1

Ingley E (2009) Csk-binding protein can regulate Lyn signals controlling cell morphology. Int J Biochem Cell Biol 41, 1332-43
19124084   Curated Info

2

Oneyama C, et al. (2008) The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src. Mol Cell 30, 426-36
18498747   Curated Info

3

Ingley E, et al. (2006) Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells. J Biol Chem 281, 31920-9
16920712   Curated Info