Ser17
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Home > Phosphorylation Site Page: > Ser17  -  Src (rat)

Site Information
DASQRRRsLEPAENV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448231

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 4 ) , phospho-antibody ( 4 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 2 ) , 'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 2 ) , 'kidney, cortex' ( 3 ) , blood ( 2 ) , IEC-6 (epithelial) ( 1 ) , intestine ( 2 ) , kidney ( 2 ) , liver ( 2 ) , lung ( 2 ) , PC-12 (chromaffin) ( 4 ) , spleen ( 2 ) , testis ( 2 ) , thymus ( 2 )

Upstream Regulation
Treatments:
8-Rp-cAMP ( 4 ) , colforsin ( 4 ) , EGF ( 4 ) , H-89 ( 4 ) , IBMX ( 4 ) , NGF ( 4 ) , serum ( 1 )

Downstream Regulation
Effects of modification on Src:
enzymatic activity, induced ( 4 )
Effects of modification on biological processes:
cell growth, altered ( 4 )

References 

1

Courcelles M, et al. (2013) Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol 9, 669
23712012   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

Feric M, et al. (2011) Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule. Am J Physiol Cell Physiol 300, C755-70
21209370   Curated Info

4

Obara Y, Labudda K, Dillon TJ, Stork PJ (2004) PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells. J Cell Sci 117, 6085-94
15546918   Curated Info