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Site Information |
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RFIGRRQsLIEDARK SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448545 |
In vivo Characterization | |
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Upstream Regulation | |
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Downstream Regulation | |
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Effects of modification on TH: | |
Effects of modification on biological processes: |
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References | |
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Wasinski F, et al. (2021) Growth hormone receptor in dopaminergic neurones regulates stress-induced prolactin release in male mice. J Neuroendocrinol 33, e12957
33769619 Curated Info |
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Becanovic K, et al. (2020) Effects of a novel psychomotor stabilizer, IRL790, on biochemical measures of synaptic markers and neurotransmission. J Pharmacol Exp Ther 374
32358047 Curated Info |
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Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257 Curated Info |
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Hua G, et al. (2015) Protein Phosphatase 2A is Involved in the Tyrosine Hydroxylase Phosphorylation Regulated by α-Synuclein. Neurochem Res 40, 428-37
25567480 Curated Info |
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Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750 Curated Info |
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Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
21454597 Curated Info |
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Ahn JH, et al. (2011) Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A. PLoS One 6, e26292
22046270 Curated Info |
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Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
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Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495 Curated Info |
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Lou H, et al. (2010) Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo. J Biol Chem 285, 17648-61
20356833 Curated Info |
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Nishi A, et al. (2008) Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum. J Neurosci 28, 10460-71
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Hoard JL, et al. (2008) Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75. Neuroscience 156, 129-42
18674600 Curated Info |
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Snyder GL, Galdi S, Hendrick JP, Hemmings HC (2007) General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo. Neuropharmacology 53, 619-30
17826804 Curated Info |
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Zhang D, et al. (2007) Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. J Neurosci 27, 5349-62
17507557 Curated Info |
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Sahin B, et al. (2007) Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling. Brain Res 1129, 1-14
17157277 Curated Info |
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Fulton S, et al. (2006) Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51, 811-22
16982425 Curated Info |
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Drolet RE, Behrouz B, Lookingland KJ, Goudreau JL (2006) Substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of alpha-synuclein. J Neurochem 96, 950-9
16412098 Curated Info |
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Salvatore MF, et al. (2005) Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice. Brain Res Mol Brain Res 139, 341-7
16051392 Curated Info |
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Kansy JW, et al. (2004) Identification of tyrosine hydroxylase as a physiological substrate for Cdk5. J Neurochem 91, 374-84
15447670 Curated Info |
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Håkansson K, et al. (2004) Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidol. Eur J Neurosci 20, 1108-12
15305880 Curated Info |
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Sawada K, et al. (2004) Abnormal expression of tyrosine hydroxylase not accompanied by phosphorylation at serine 40 in cerebellar Purkinje cells of ataxic mutant mice, rolling mouse Nagoya and dilute-lethal. Congenit Anom (Kyoto) 44, 46-50
15008900 Curated Info |
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Lindgren N, et al. (2003) Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites. Proc Natl Acad Sci U S A 100, 4305-9
12651945 Curated Info |