Ser19
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Home > Phosphorylation Site Page: > Ser19  -  TH (mouse)

Site Information
KGFRRAVsEQDtKQA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448542

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 8 ) , mass spectrometry ( 4 , 5 , 6 , 7 , 9 , 10 , 11 ) , phospho-antibody ( 1 , 3 , 8 , 12 , 13 ) , western blotting ( 1 , 3 , 8 )
Disease tissue studied:
neuroblastoma ( 5 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 1 , 13 ) , 'fat, brown' ( 6 ) , 'neuron, cortical'-brain ( 12 ) , 'neuron, ventral tegmental'-brain ( 3 ) , brain ( 7 ) , heart ( 4 ) , liver ( 9 , 10 , 11 ) , MN9D ('neuron, mesencephalic') ( 8 ) , N1E-115 (neuron) ( 5 )

Upstream Regulation
Regulatory protein:
AHCYL1 (human) ( 3 ) , IREB2 (mouse) ( 13 ) , SNCA (human) ( 8 ) , SNCA (mouse) ( 12 )
Putative upstream phosphatases:
PPP2CA (human) ( 8 )
Treatments:
fostriecin ( 8 ) , LPA ( 5 ) , okadaic_acid ( 8 ) , raclopride ( 12 ) , tyrosine ( 12 )

Downstream Regulation
Effects of modification on TH:
phosphorylation ( 8 )
Effects of modification on biological processes:
neural plasticity ( 1 )

References 

1

Becanovic K, et al. (2020) Effects of a novel psychomotor stabilizer, IRL790, on biochemical measures of synaptic markers and neurotransmission. J Pharmacol Exp Ther
32358047   Curated Info

2

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

3

Kawaai K, et al. (2015) IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. Proc Natl Acad Sci U S A 112, 5515-20
25922519   Curated Info

4

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

5

Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
21454597   Curated Info

6

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

7

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

8

Lou H, et al. (2010) Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo. J Biol Chem 285, 17648-61
20356833   Curated Info

9

Possemato A (2009) CST Curation Set: 8045; Year: 2009; Biosample/Treatment: tissue, liver/control; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

10

Possemato A (2009) CST Curation Set: 8044; Year: 2009; Biosample/Treatment: tissue, liver/control; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

11

Possemato A (2009) CST Curation Set: 8046; Year: 2009; Biosample/Treatment: tissue, liver/AICAR; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

12

Drolet RE, Behrouz B, Lookingland KJ, Goudreau JL (2006) Substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of alpha-synuclein. J Neurochem 96, 950-9
16412098   Curated Info

13

Salvatore MF, et al. (2005) Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice. Brain Res Mol Brain Res 139, 341-7
16051392   Curated Info