Ser364
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser364  -  DUSP1 (human)

Site Information
LQsPITTsPSC____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448661

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 , 2 )
Kinases, in vitro:
ERK1 (human) ( 2 )
Treatments:
estradiol ( 2 ) , LPS ( 1 ) , PD98059 ( 2 ) , serum ( 2 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on DUSP1:
protein stabilization ( 1 , 2 )

References 

1

Crowell S, et al. (2014) Post-translational Regulation of Mitogen-activated Protein Kinase Phosphatase (MKP)-1 and MKP-2 in Macrophages Following Lipopolysaccharide Stimulation: THE ROLE OF THE C TERMINI OF THE PHOSPHATASES IN DETERMINING THEIR STABILITY. J Biol Chem 289, 28753-64
25204653   Curated Info

2

Brondello JM, Pouysségur J, McKenzie FR (1999) Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 286, 2514-7
10617468   Curated Info