Ser359
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Home > Phosphorylation Site Page: > Ser359  -  DUSP1 (human)

Site Information
SALSYLQsPITTsPS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448660

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
liver cancer ( 2 ) , hepatocellular carcinoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
HSP27 (human) ( 2 )
Putative in vivo kinases:
ERK1 (human) ( 1 , 3 )
Kinases, in vitro:
ERK1 (human) ( 3 )
Treatments:
estradiol ( 3 ) , LPS ( 1 ) , PD98059 ( 3 ) , serum ( 3 ) , TNF ( 2 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on DUSP1:
protein stabilization ( 1 , 3 )

References 

1

Crowell S, et al. (2014) Post-translational Regulation of Mitogen-activated Protein Kinase Phosphatase (MKP)-1 and MKP-2 in Macrophages Following Lipopolysaccharide Stimulation: THE ROLE OF THE C TERMINI OF THE PHOSPHATASES IN DETERMINING THEIR STABILITY. J Biol Chem 289, 28753-64
25204653   Curated Info

2

Matsushima-Nishiwaki R, et al. (2008) Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase. J Biol Chem 283, 18852-60
18477563   Curated Info

3

Brondello JM, Pouysségur J, McKenzie FR (1999) Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 286, 2514-7
10617468   Curated Info