Thr89

Site Information
PssKsVstPsEAGsQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 469264

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 , 5 )
Disease tissue studied:	neuroblastoma ( 3 )
Relevant cell line - cell type - tissue:	'fat, brown' ( 4 ) , brain ( 4 , 5 ) , heart ( 4 ) , macrophage-peritoneum ( 2 ) , N1E-115 (neuron) ( 3 ) , pancreas ( 4 ) , spleen ( 4 )

Upstream Regulation
Treatments:	LPA ( 3 )

References
1	Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250 27841257 Curated Info
2	Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51 22942356 Curated Info
3	Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201 21454597 Curated Info
4	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
5	Zhou J (2008) CST Curation Set: 3807; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P , PTMScan(R) PLK Binding Motif (SpTP) Immunoaffinity Beads Cat#: 1995 Curated Info