Thr6
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Home > Phosphorylation Site Page: > Thr6  -  DFNA5 (human)

Site Information
__MFAkAtRNFLREV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 50777052

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Disease tissue studied:
melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:
A375 (melanocyte) ( 1 ) , CEM-C7 cell line ( 2 ) , HEK293T (epithelial) ( 2 )

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (human) ( 1 ) , AMPKA2 (human) ( 1 )
Kinases, in vitro:
AMPKA1 (human) ( 1 )
Treatments:
dorsomorphin ( 1 ) , mannose ( 1 ) , metformin ( 1 ) , MK8722 ( 1 )

Downstream Regulation
Effects of modification on DFNA5:
activity, inhibited ( 2 ) , intracellular localization ( 2 ) , molecular association, regulation ( 1 , 2 ) , protein conformation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , signaling pathway regulation ( 2 )
Inhibit interaction with:
CASP3 (human) ( 1 ) , DFNA5 (human) ( 2 )

References 

1

Ai YL, et al. (2023) Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P. Cell Res
37460805   Curated Info

2

Rogers C, et al. (2019) Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. Nat Commun 10, 1689
30976076   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info