Tyr463
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Home > Phosphorylation Site Page: > Tyr463  -  PRKD1 (human)

Site Information
NDTGsRYyKEIPLSE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448648

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 , 6 ) , mutation of modification site ( 1 , 2 , 4 , 5 , 6 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 5 , 6 ) , Src (human) ( 5 , 6 )
Kinases, in vitro:
Abl (human) ( 5 , 6 )
Treatments:
bradykinin ( 6 ) , H2O2 ( 1 , 3 , 6 ) , phorbol_ester ( 6 ) , resveratrol ( 3 ) , vanadate ( 6 ) , VEGF ( 2 )

Downstream Regulation
Effects of modification on PRKD1:
enzymatic activity, induced ( 1 , 4 , 5 , 6 ) , phosphorylation ( 2 , 4 ) , protein conformation ( 4 )
Effects of modification on biological processes:
apoptosis, inhibited ( 6 ) , cell differentiation, altered ( 2 ) , cell growth, altered ( 2 ) , transcription, altered ( 4 ) , transcription, induced ( 6 )

References 

1

Döppler H, Storz P (2007) A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation. J Biol Chem 282, 31873-81
17804414   Curated Info

2

Qin L, Zeng H, Zhao D (2006) Requirement of protein kinase D tyrosine phosphorylation for VEGF-A165-induced angiogenesis through its interaction and regulation of phospholipase Cgamma phosphorylation. J Biol Chem 281, 32550-8
16891660   Curated Info

3

Storz P, Döppler H, Toker A (2004) Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB. Mol Pharmacol 66, 870-9
15226414   Curated Info

4

Storz P, Döppler H, Toker A (2004) Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol 24, 2614-26
15024053   Curated Info

5

Storz P, Döppler H, Johannes FJ, Toker A (2003) Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. J Biol Chem 278, 17969-76
12637538   Curated Info

6

Storz P, Toker A (2003) Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J 22, 109-20
12505989   Curated Info