Ser478
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Home > Phosphorylation Site Page: > Ser478  -  PER2 (mouse)

Site Information
PVPHSGSsGYGSLGS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 50596800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
familial advanced sleep phase syndrome ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , MEF (fibroblast) ( 2 )

Downstream Regulation
Effects of modification on PER2:
molecular association, regulation ( 2 ) , protein degradation ( 1 , 2 )
Induce interaction with:
BTRC (mouse) ( 2 )

References 

1

Eng GWL, Edison, Virshup DM (2017) Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2. PLoS One 12, e0177834
28545154   Curated Info

2

Zhou M, et al. (2015) A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period. Mol Cell 60, 77-88
26431025   Curated Info