Ser439
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Home > Phosphorylation Site Page: > Ser439  -  SREBP-1 (human)

Site Information
AGsPFQSsPLSLGSR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 469115

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
CDK1 (human) ( 1 )
Kinases, in vitro:
CDK1 (human) ( 1 )
Treatments:
nocodazole ( 1 ) , purvalanol ( 1 ) , seliciclib ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on SREBP-1:
protein stabilization ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , transcription, induced ( 1 )

References 

1

Bengoechea-Alonso MT, Ericsson J (2006) Cdk1/cyclin B-mediated phosphorylation stabilizes SREBP1 during mitosis. Cell Cycle 5, 1708-18
16880739   Curated Info

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