Tyr782
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Home > Phosphorylation Site Page: > Tyr782  -  DDEF1 (mouse)

Site Information
RDKQRLSyGAFTNQI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450438

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 3 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , A375 (melanocyte) ( 1 ) , HeLa (cervical) ( 1 )

Upstream Regulation
Regulatory protein:
KDELR1 (mouse) ( 1 )
Kinases, in vitro:
Pyk2 (human) ( 2 )
Treatments:
SU6656 ( 1 ) , temperature-block release ( 1 )

Downstream Regulation
Effects of modification on DDEF1:
activity, inhibited ( 2 , 3 ) , molecular association, regulation ( 2 )
Inhibit interaction with:
Other ( 2 )

References 

1

Ruggiero C, et al. (2018) The KDEL receptor signalling cascade targets focal adhesion kinase on focal adhesions and invadopodia. Oncotarget 9, 10228-10246
29535802   Curated Info

2

Kruljac-Letunic A, Blaukat A (2005) Assay and functional properties of the tyrosine kinase Pyk2 in regulation of Arf1 through ASAP1 phosphorylation. Methods Enzymol 404, 411-22
16413287   Curated Info

3

Kruljac-Letunic A, et al. (2003) The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. J Biol Chem 278, 29560-70
12771146   Curated Info

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