Tyr526
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Home > Phosphorylation Site Page: > Tyr526  -  hnRNP P2 (human)

Site Information
QDrrErPy_______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 50318713

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, frontal cortex' ( 1 ) , 'neuron, cortical' ( 2 ) , 'neuron, cortical'-brain ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 2 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Regulatory protein:
Fyn (human) ( 1 ) , Src (human) ( 1 )
Putative in vivo kinases:
Abl (human) ( 1 ) , Fyn (human) ( 2 ) , Src (human) ( 2 )
Treatments:
PP2 ( 2 ) , vanadate ( 2 )

Downstream Regulation
Effects of modification on hnRNP P2:
intracellular localization ( 1 , 2 ) , molecular association, regulation ( 2 )
Inhibit interaction with:
KPNB2 (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
FTLD ( 1 )

References 

1

Motaln H, et al. (2023) Abl kinase-mediated FUS Tyr526 phosphorylation alters nucleocytoplasmic FUS localization in FTLD-FUS. Brain
37071594   Curated Info

2

Darovic S, et al. (2015) Phosphorylation of C-terminal tyrosine residue 526 in FUS impairs its nuclear import. J Cell Sci 128, 4151-9
26403203   Curated Info

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