Ser258
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Home > Phosphorylation Site Page: > Ser258  -  AP-2 alpha (human)

Site Information
GVLRRAKsKNGGRSL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 5024712

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , acute myelogenous leukemia ( 1 ) , liver cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
PRKD1 (human) ( 1 )

Downstream Regulation
Effects of modification on AP-2 alpha:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, altered ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Iwamoto N, Abe-Dohmae S, Lu R, Yokoyama S (2008) Involvement of protein kinase D in phosphorylation and increase of DNA binding of activator protein 2 alpha to downregulate ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol 28, 2282-7
18845787   Curated Info