Ser106
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Home > Phosphorylation Site Page: > Ser106  -  Bcl-xL (rat)

Site Information
LRYRRAFsDLTSQLH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 5014911

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Akt1 (rat) ( 1 )

Downstream Regulation
Effects of modification on Bcl-xL:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, altered ( 1 )
Induce interaction with:
Akt1 (rat) ( 1 )
Inhibit interaction with:
VDAC1 (rat) ( 1 )

References 

1

Wei Z, et al. (2009) Haloperidol disrupts Akt signalling to reveal a phosphorylation-dependent regulation of pro-apoptotic Bcl-XS function. Cell Signal 21, 161-8
18951975   Curated Info