Ser202

Site Information
HEFIRSEsENWRIFR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 468967

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 )
Relevant cell line - cell type - tissue:	'fat, brown' ( 8 ) , 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 9 ) , 32Dcl3 (myeloid) ( 9 ) , brain ( 8 ) , heart ( 5 , 8 ) , kidney ( 8 ) , liver ( 4 , 6 , 8 , 10 , 11 ) , liver [leptin (mouse), homozygous knockout] ( 6 ) , lung ( 8 ) , pancreas ( 8 ) , RAW 264.7 (macrophage) ( 2 ) , spleen ( 8 ) , T lymphocyte-spleen ( 7 )

In vivo Characterization

Methods used to characterize site in vivo:

mass spectrometry ( 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 )

Relevant cell line - cell type - tissue:

'fat, brown' ( 8 ) , 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 9 ) , 32Dcl3 (myeloid) ( 9 ) , brain ( 8 ) , heart ( 5 , 8 ) , kidney ( 8 ) , liver ( 4 , 6 , 8 , 10 , 11 ) , liver [leptin (mouse), homozygous knockout] ( 6 ) , lung ( 8 ) , pancreas ( 8 ) , RAW 264.7 (macrophage) ( 2 ) , spleen ( 8 ) , T lymphocyte-spleen ( 7 )

Upstream Regulation
Regulatory protein:	ADRB1 (mouse) ( 5 )
Treatments:	IL-33 ( 2 )

References
1	Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250 27841257 Curated Info
2	Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44 25367039 Curated Info
3	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
4	Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86 23567750 Curated Info
5	Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11 23737553 Curated Info
6	Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83 23140645 Curated Info
7	Navarro MN, et al. (2011) Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat Immunol 12, 352-61 21399638 Curated Info
8	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
9	Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39 19854140 Curated Info
10	Possemato A (2009) CST Curation Set: 8043; Year: 2011; Biosample/Treatment: tissue, liver/AICAR; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Curated Info
11	Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93 17242355 Curated Info