Ser62
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Home > Phosphorylation Site Page: > Ser62  -  TH (human)

Site Information
SYTPTPRsPRFIGRR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448544

Upstream Regulation
Kinases, in vitro:
ERK1 (human) ( 2 , 3 ) , ERK2 (human) ( 1 , 2 )

Downstream Regulation
Effects of modification on TH:
enzymatic activity, induced ( 3 )

References 

1

Lehmann IT, et al. (2006) Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation. J Biol Chem 281, 17644-51
16644734   Curated Info

2

Kleppe R, Toska K, Haavik J (2001) Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association. J Neurochem 77, 1097-107
11359875   Curated Info

3

Sutherland C, et al. (1993) Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. Eur J Biochem 217, 715-22
7901013   Curated Info