Ser19
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Home > Phosphorylation Site Page: > Ser19  -  TH (human)

Site Information
KGFRRAVsELDAKQA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448542

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 5 ) , phospho-antibody ( 6 )
Disease tissue studied:
neuroblastoma ( 5 )
Relevant cell line - cell type - tissue:
BE(2)-C (glial) ( 6 ) , NB10 (neural crest) ( 5 ) , NPC (neural crest) ( 5 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (human) ( 6 )
Kinases, in vitro:
CAMK2A (human) ( 9 ) , CAMK2A (rat) ( 8 ) , MAPKAPK2 (human) ( 7 , 8 )
Phosphatases, in vitro:
PPP2CA (human) ( 7 )
Treatments:
AIDA ( 6 ) , CNQX ( 6 ) , CPP ( 6 ) , GDNF ( 6 ) , LY341495 ( 6 ) , MCCG ( 6 ) , MK801 ( 6 ) , MSOP ( 6 ) , serum_starvation ( 6 )

Downstream Regulation
Effects of modification on TH:
enzymatic activity, induced ( 6 ) , molecular association, regulation ( 3 ) , protein conformation ( 3 )
Induce interaction with:
14-3-3 gamma (human) ( 3 )

References 

1

Won SY, et al. (2021) cAMP Response Element Binding-Protein- and Phosphorylation-Dependent Regulation of Tyrosine Hydroxylase by PAK4: Implications for Dopamine Replacement Therapy. Mol Cells 44, 493-499
34238765   Curated Info

2

Waløen K, et al. (2021) . Mol Pharmacol
34031189   Curated Info

3

Skjevik AA, et al. (2014) The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. J Mol Biol 426, 150-68
24055376   Curated Info

4

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

5

DeNardo BD, et al. (2013) Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma. PLoS One 8, e82513
24349301   Curated Info

6

Kobori N, Moore AN, Dash PK (2006) GDNF abates serum deprivation-induced tyrosine hydroxylase Ser19 phosphorylation and activity. Brain Res 1086, 142-51
16626642   Curated Info

7

Kleppe R, Toska K, Haavik J (2001) Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association. J Neurochem 77, 1097-107
11359875   Curated Info

8

Sutherland C, et al. (1993) Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. Eur J Biochem 217, 715-22
7901013   Curated Info

9

Le Bourdellès B, et al. (1991) Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: an additional phosphorylated residue in isoform 2, generated through alternative splicing. J Biol Chem 266, 17124-30
1680128   Curated Info