Ser311
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Home > Phosphorylation Site Page: > Ser311  -  MEK5 (human)

Site Information
VSTQLVNsIAKtYVG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448621

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 ) , mutation of modification site ( 5 , 6 ) , western blotting ( 6 )
Disease tissue studied:
breast cancer ( 3 ) , breast ductal carcinoma ( 3 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
ischemia ( 3 )

Downstream Regulation
Effects of modification on MEK5:
enzymatic activity, induced ( 5 ) , intracellular localization ( 5 ) , molecular association, regulation ( 6 )
Inhibit interaction with:
ERK5 (human) ( 6 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

5

Cameron SJ, et al. (2004) Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation. J Biol Chem 279, 1506-12
14583600   Curated Info

6

Zhou G, Bao ZQ, Dixon JE (1995) Components of a new human protein kinase signal transduction pathway. J Biol Chem 270, 12665-9
7759517   Curated Info