Ser125
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser125  -  STX7 (mouse)

Site Information
FVARVRAssRVsGGF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 468880

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , electrophoretic mobility shift ( 5 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 6 ) , mutation of modification site ( 5 ) , western blotting ( 5 )
Disease tissue studied:
anthrax infection ( 1 )
Relevant cell line - cell type - tissue:
fibroblast-lung ( 4 ) , kidney ( 2 ) , liver ( 6 ) , lung ( 2 ) , macrophage-bone marrow ( 3 , 5 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 3 ) , spleen ( 1 , 2 ) , testis ( 2 )

Upstream Regulation
Regulatory protein:
PIK3C2A (mouse) ( 5 )
Putative in vivo kinases:
PKCA (mouse) ( 5 )
Treatments:
Akt_inhibitor_VIII ( 5 ) , GF109203X ( 5 ) , M-CSF ( 5 ) , phorbol_ester ( 5 )

Downstream Regulation
Effects of modification on STX7:
molecular association, regulation ( 5 )
Induce interaction with:
STX8 (mouse) ( 5 ) , VAMP8 (mouse) ( 5 ) , VTI1B (mouse) ( 5 )

References 

1

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

3

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

4

Guo A (2010) CST Curation Set: 9029; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

5

Achuthan A, et al. (2008) Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages. Mol Cell Biol 28, 6149-59
18710945   Curated Info

6

Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93
17242355   Curated Info