Ser292
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Home > Phosphorylation Site Page: > Ser292  -  Rin1 (human)

Site Information
QLLRREssVGyRVPA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4949757

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ) , microscopy-colocalization with upstream kinase ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
breast cancer ( 2 ) , lung cancer ( 3 ) , non-small cell squamous cell lung carcinoma ( 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , COS (fibroblast) ( 2 ) , HeLa (cervical) ( 1 ) , HSF (fibroblast) ( 1 ) , MCF-7 (breast cell) ( 2 ) , MKN-45 (gastric) ( 7 , 8 ) , NCI-H1650 (pulmonary) ( 4 ) , NCI-H1703 (squamous) ( 3 , 5 , 6 )

Upstream Regulation
Putative in vivo kinases:
PRKD1 (human) ( 2 ) , PRKD2 (human) ( 2 )
Kinases, in vitro:
PRKD1 (human) ( 2 )
Treatments:
Go_6976 ( 2 ) , Go_6983 ( 2 ) , PGE2 ( 1 ) , phorbol_ester ( 2 )

Downstream Regulation
Effects of modification on Rin1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell motility, altered ( 2 ) , cell motility, inhibited ( 1 )
Induce interaction with:
HRas (human) ( 1 )

References 

1

Gerarduzzi C, et al. (2017) Prostaglandin E2-Dependent Phosphorylation of RAS Inhibition 1 (RIN1) at Ser 291 and 292 Inhibits Transforming Growth Factor-β-Induced RAS Activation Pathway in Human Synovial Fibroblasts: Role in Cell Migration. J Cell Physiol 232, 202-15
27137893   Curated Info

2

Ziegler S, et al. (2011) A novel protein kinase D phosphorylation site in the tumor suppressor Rab interactor 1 is critical for coordination of cell migration. Mol Biol Cell 22, 570-80
21209314   Curated Info

3

Moritz A, et al. (2010) Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases. Sci Signal 3, ra64
20736484   Curated Info

4

Possemato A (2009) CST Curation Set: 8049; Year: 2009; Biosample/Treatment: cell line, NCI-H1650/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

5

Moritz A (2009) CST Curation Set: 5880; Year: 2009; Biosample/Treatment: cell line, NCI-H1703/rapamycin; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

6

Moritz A (2009) CST Curation Set: 5883; Year: 2009; Biosample/Treatment: cell line, NCI-H1703/U 0126; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

7

Moritz A (2008) CST Curation Set: 5525; Year: 2008; Biosample/Treatment: cell line, MKN-45/rapamycin; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

8

Moritz A (2008) CST Curation Set: 5529; Year: 2008; Biosample/Treatment: cell line, MKN-45/U 0126; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

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