Thr423
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr423  -  PAK1 (mouse)

Site Information
PEQSKRstMVGtPYW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448177

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 4 ) , mass spectrometry ( 1 , 2 ) , phospho-antibody ( 3 , 4 , 5 ) , western blotting ( 3 , 4 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 5 ) , liver ( 2 ) , mast-bone marrow [PTPRA (mouse), homozygous knockout] ( 3 ) , MEF (fibroblast) ( 1 ) , neutrophil ( 4 )

Upstream Regulation
Treatments:
fMLP ( 4 ) , IFN-gamma ( 5 ) , SCF ( 3 ) , virus infection ( 5 )

Downstream Regulation
Effects of modification on PAK1:
enzymatic activity, induced ( 5 )

References 

1

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

2

Guo A (2011) CST Curation Set: 12478; Year: 2011; Biosample/Treatment: tissue, liver/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

3

Samayawardhena LA, Pallen CJ (2008) Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells. J Biol Chem 283, 29175-85
18725415   Curated Info

4

Zhan Q, et al. (2003) p21-activated kinase 2 in neutrophils can be regulated by phosphorylation at multiple sites and by a variety of protein phosphatases. J Immunol 171, 3785-93
14500679   Curated Info

5

Johnston JB, et al. (2003) Role of the serine-threonine kinase PAK-1 in myxoma virus replication. J Virol 77, 5877-88
12719581   Curated Info