Ser898

Site Information
LEGGRSDsLrsFSSD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4691011

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 )
Disease tissue studied:	HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , lung cancer ( 4 ) , non-small cell lung cancer ( 4 ) , ovarian cancer ( 2 ) , pancreatic ductal adenocarcinoma ( 3 )
Relevant cell line - cell type - tissue:	'pancreatic, ductal'-pancreas ( 3 ) , 293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] ( 6 ) , breast ( 1 ) , H2077 (pulmonary) ( 4 ) , H322M (pulmonary) ( 4 ) , HCC827 (pulmonary) ( 4 ) , HUES-9 ('stem, embryonic') ( 5 ) , LCLC-103H (pulmonary) ( 4 ) , ovary ( 2 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
3	Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948 24670416 Curated Info
4	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
5	Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3 21406692 Curated Info
6	Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53 20363803 Curated Info