Ser178
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Home > Phosphorylation Site Page: > Ser178  -  PXN iso2 (human)

Site Information
PPLPGALsPLyGVPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448603

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 ) , western blotting ( 1 , 2 , 3 , 4 , 5 )
Disease tissue studied:
breast cancer ( 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
E4 (adenovirus) ( 3 ) , JNK1 (human) ( 1 , 3 )
Treatments:
Ox-PAPC ( 4 ) , PAR2-activating_peptide ( 2 ) , PDGF ( 5 ) , PP1 ( 2 ) , SP600125 ( 2 , 5 ) , trypsin ( 2 )

Downstream Regulation
Effects of modification on PXN iso2:
intracellular localization ( 3 ) , protein stabilization ( 3 )
Effects of modification on biological processes:
cell adhesion, altered ( 3 ) , cytoskeletal reorganization ( 3 )

References 

1

Lee MH, Koria P, Qu J, Andreadis ST (2009) JNK phosphorylates beta-catenin and regulates adherens junctions. FASEB J 23, 3874-83
19667122   Curated Info

2

Su S, et al. (2009) Proteinase-activated receptor 2 expression in breast cancer and its role in breast cancer cell migration. Oncogene 28, 3047-57
19543320   Curated Info

3

Smadja-Lamère N, et al. (2008) JNK-mediated phosphorylation of paxillin in adhesion assembly and tension-induced cell death by the adenovirus death factor E4orf4. J Biol Chem 283, 34352-64
18818208   Curated Info

4

Birukova AA, et al. (2008) Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol 295, L593-602
18676874   Curated Info

5

Amagasaki K, Kaneto H, Heldin CH, Lennartsson J (2006) c-Jun N-terminal kinase is necessary for platelet-derived growth factor-mediated chemotaxis in primary fibroblasts. J Biol Chem 281, 22173-9
16760468   Curated Info