Thr140
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Home > Phosphorylation Site Page: > Thr140  -  p21Cip1 (mouse)

Site Information
QGRKRRQtsLTDFYH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447837

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lymphoma ( 2 ) , anaplastic large cell lymphoma ( 2 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 1 ) , TS (lymphocyte) ( 2 )

Upstream Regulation
Regulatory protein:
Chk1 (human) ( 2 )
Putative in vivo kinases:
Chk1 (human) ( 2 )
Kinases, in vitro:
Akt1 (human) ( 1 ) , Chk1 (human) ( 2 )

Downstream Regulation
Effects of modification on p21Cip1:
activity, inhibited ( 2 ) , intracellular localization ( 1 ) , protein stabilization ( 1 )

References 

1

de Renty C, DePamphilis ML, Ullah Z (2014) Cytoplasmic Localization of p21 Protects Trophoblast Giant Cells from DNA Damage Induced Apoptosis. PLoS One 9, e97434
24848107   Curated Info

2

Ullah Z, de Renty C, DePamphilis ML (2011) Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation. Mol Cell Biol 31, 4129-43
21791608   Curated Info