Ser141
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Home > Phosphorylation Site Page: > Ser141  -  p21Cip1 (mouse)

Site Information
GRKRRQtsLTDFYHS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447836

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , [32P] bio-synthetic labeling ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
lymphoma ( 3 ) , anaplastic large cell lymphoma ( 3 ) , BCC ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Chk1 (human) ( 3 )
Kinases, in vitro:
Akt1 (human) ( 2 ) , Chk1 (human) ( 3 ) , NuaK1 (human) ( 1 )

Downstream Regulation
Effects of modification on p21Cip1:
activity, inhibited ( 3 ) , intracellular localization ( 2 ) , protein stabilization ( 2 )

References 

1

Esteve-Puig R, et al. (2014) A Mouse Model Uncovers LKB1 as an UVB-Induced DNA Damage Sensor Mediating CDKN1A (p21WAF1/CIP1) Degradation. PLoS Genet 10, e1004721
25329316   Curated Info

2

de Renty C, DePamphilis ML, Ullah Z (2014) Cytoplasmic Localization of p21 Protects Trophoblast Giant Cells from DNA Damage Induced Apoptosis. PLoS One 9, e97434
24848107   Curated Info

3

Ullah Z, de Renty C, DePamphilis ML (2011) Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation. Mol Cell Biol 31, 4129-43
21791608   Curated Info