Ser1786

Site Information
ItQsPGRssVAsPRR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 468163

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 )
Disease tissue studied:	breast cancer ( 4 ) , lung cancer ( 5 ) , neuroblastoma ( 3 ) , pancreatic ductal adenocarcinoma ( 2 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:	'pancreatic, ductal'-pancreas ( 2 ) , 293 (epithelial) [AT1 (human), transfection] ( 6 ) , A498 (renal) ( 7 ) , CL1-0 (pulmonary) ( 5 ) , CL1-1 (pulmonary) ( 5 ) , CL1-2 (pulmonary) ( 5 ) , CL1-5 (pulmonary) ( 5 ) , HCC1937 (breast cell) ( 4 ) , MCF-7 (breast cell) ( 4 ) , NB10 (neural crest) ( 3 ) , NPC (neural crest) ( 3 ) , WM239A (melanocyte) ( 1 )

Upstream Regulation
Treatments:	metastatic potential ( 5 )

References
1	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
2	Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948 24670416 Curated Info
3	DeNardo BD, et al. (2013) Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma. PLoS One 8, e82513 24349301 Curated Info
4	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
5	Wang YT, et al. (2010) An informatics-assisted label-free quantitation strategy that depicts phosphoproteomic profiles in lung cancer cell invasion. J Proteome Res 9, 5582-97 20815410 Curated Info
6	Xiao K, et al. (2010) Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A 107, 15299-304 20686112 Curated Info
7	Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62 20071362 Curated Info