Thr263
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Home > Phosphorylation Site Page: > Thr263  -  PGC-1 alpha (human)

Site Information
TTLSLPLtPEsPNDP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448241

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , electrophoretic mobility shift ( 2 ) , mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 2 ) , BOSC ( 2 ) , C2C12 (myoblast) ( 2 ) , hepatocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
P38A (human) ( 2 )
Kinases, in vitro:
P38A (human) ( 2 )
Treatments:
SB202190 ( 2 )

Downstream Regulation
Effects of modification on PGC-1 alpha:
protein stabilization ( 2 )

References 

1

Wang W, Wong CW (2010) Statins enhance peroxisome proliferator-activated receptor gamma coactivator-1alpha activity to regulate energy metabolism. J Mol Med 88, 309-17
19915805   Curated Info

2

Puigserver P, et al. (2001) Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell 8, 971-82
11741533   Curated Info