Ser16
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Home > Phosphorylation Site Page: > Ser16  -  PIN1 (mouse)

Site Information
PGWEkRMsRSSGRVY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447772

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 2 )

Upstream Regulation
Putative in vivo kinases:
PKCZ (mouse) ( 1 )
Kinases, in vitro:
PKCZ (mouse) ( 1 )
Treatments:
H2O2 ( 2 ) , okadaic_acid ( 2 )

Downstream Regulation
Effects of modification on PIN1:
enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:
translation, altered ( 1 )

References 

1

Westmark PR, et al. (2010) Pin1 and PKMzeta sequentially control dendritic protein synthesis. Sci Signal 3, ra18
20215645   Curated Info

2

Galas MC, et al. (2006) The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. J Biol Chem 281, 19296-304
16675464   Curated Info