Ser135

Site Information
RRHGsMVsLVsGAsG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4777474

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 3 , 4 , 5 , 6 , 7 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 )
Disease tissue studied:	colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , lung cancer ( 4 ) , non-small cell lung cancer ( 4 )
Relevant cell line - cell type - tissue:	B lymphocyte-blood ( 1 ) , Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] ( 5 ) , Flp-In T-Rex-293 (epithelial) ( 5 ) , HCC2279 (pulmonary) ( 4 ) , HCC827 (pulmonary) ( 4 ) , HCT116 (intestinal) ( 1 ) , Jurkat (T lymphocyte) ( 6 , 7 ) , LCLC-103H (pulmonary) ( 4 ) , MCF-7 (breast cell) ( 3 ) , NCI-H2172 (pulmonary) ( 4 )

Downstream Regulation
Effects of modification on COL4A3BP:	activity, inhibited ( 1 , 2 ) , intracellular localization ( 1 ) , molecular association, regulation ( 2 )

References
1	Murakami H, et al. (2020) Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT. PLoS One 15, e0243980 33347465 Curated Info
2	Prashek J, et al. (2017) Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain. J Biol Chem 292, 14217-14228 28652409 Curated Info
3	Sacco F, et al. (2016) Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State. Cell Syst 2, 159-71 27135362 Curated Info
4	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
5	Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70 22496350 Curated Info
6	Mulhern D (2012) CST Curation Set: 13828; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XpSX(K/R) Curated Info
7	Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46 19690332 Curated Info