Ser293
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Home > Phosphorylation Site Page: > Ser293  -  calponin 3 (human)

Site Information
QGtGTNGsEIsDSDy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4776192

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , liver cancer ( 3 ) , liver adenocarcinoma ( 3 ) , urethral cancer ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , BeWo ( 2 ) , breast ( 1 ) , HeLa (cervical) ( 4 ) , SK-HEP-1 (endothelial) ( 3 )

Upstream Regulation
Kinases, in vitro:
ROCK2 (human) ( 2 )
Treatments:
colforsin ( 2 )

Downstream Regulation
Effects of modification on calponin 3:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Shibukawa Y, et al. (2010) Calponin 3 Regulates Actin Cytoskeleton Rearrangement in Trophoblastic Cell Fusion. Mol Biol Cell 21, 3973-3984
20861310   Curated Info

3

Tucker M (2009) CST Curation Set: 6887; Year: 2009; Biosample/Treatment: cell line, SK-HEP-1/untreated; Disease: liver adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Zhou J (2008) CST Curation Set: 4842; Year: 2008; Biosample/Treatment: cell line, HeLa/UV; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate Motif (pS/pTQG) Antibody Cat#: 5074, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQG) Immunoaffinity Beads Cat#: 1993
Curated Info

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