Ser1178
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Home > Phosphorylation Site Page: > Ser1178  -  eNOS (mouse)

Site Information
RIRtQsFsLQERQLR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467802

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 4 , 6 ) , microscopy-colocalization with upstream kinase ( 3 ) , phospho-antibody ( 3 , 5 , 7 ) , western blotting ( 5 )
Disease tissue studied:
kidney cancer ( 5 )
Relevant cell line - cell type - tissue:
'brain, embryonic' ( 4 ) , aorta ( 3 ) , BAEC (endothelial) ( 5 ) , endothelial-aorta ( 7 ) , heart ( 1 ) , liver ( 2 , 6 ) , liver [leptin (mouse), homozygous knockout] ( 2 ) , microvessel-kidney ( 5 )

Upstream Regulation
Regulatory protein:
ICAM1 (mouse) ( 7 )
Treatments:
CRP ( 5 ) , insulin ( 5 )

Downstream Regulation
Effects of modification on eNOS:
intracellular localization ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
atherosclerosis ( 3 )

References 

1

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

2

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

3

Won D, et al. (2007) Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow. Am J Pathol 171, 1691-704
17982133   Curated Info

4

Guo A (2007) CST Curation Set: 2677; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851
Curated Info

5

Xu JW, et al. (2007) C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase. Mol Endocrinol 21, 564-73
17095576   Curated Info

6

Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93
17242355   Curated Info

7

Kevil CG, et al. (2004) Intercellular adhesion molecule-1 (ICAM-1) regulates endothelial cell motility through a nitric oxide-dependent pathway. J Biol Chem 279, 19230-8
14985356   Curated Info