Ser218
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Home > Phosphorylation Site Page: > Ser218  -  RGS18 (human)

Site Information
NLRRRsRsFTCNEFQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4772688

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 , 2 ) , platelet-blood ( 1 , 2 )

Upstream Regulation
Treatments:
colforsin ( 1 ) , epoprostenol ( 1 )

Downstream Regulation
Effects of modification on RGS18:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
signaling pathway regulation ( 2 )
Induce interaction with:
14-3-3 gamma (human) ( 2 )
Inhibit interaction with:
14-3-3 gamma (human) ( 1 )

References 

1

Gegenbauer K, Nagy Z, Smolenski A (2013) Cyclic nucleotide dependent dephosphorylation of regulator of g-protein signaling 18 in human platelets. PLoS One 8, e80251
24244663   Curated Info

2

Gegenbauer K, Elia G, Blanco-Fernandez A, Smolenski A (2012) Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets. Blood 119, 3799-807
22234696   Curated Info

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