Ser310
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Home > Phosphorylation Site Page: > Ser310  -  WAVE1 (mouse)

Site Information
LIENRPQsPAAGRTP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4764996

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 6 ) , phospho-antibody ( 1 , 4 , 5 ) , western blotting ( 1 , 4 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 2 ) , 'brain, cerebral cortex' ( 4 ) , 'brain, hippocampus' ( 4 ) , 'neuron, striatal'-brain ( 5 ) , brain ( 1 , 3 , 6 )

Upstream Regulation
Regulatory protein:
CCNE2 (mouse) ( 4 )
Putative upstream phosphatases:
PPP2CA (mouse) ( 5 )
Treatments:
ciclosporin ( 5 ) , cocaine ( 1 ) , colforsin ( 5 ) , MK801 ( 1 ) , NMDA ( 5 ) , okadaic_acid ( 5 ) , quinpirole ( 5 ) , SCH_23390 ( 1 ) , tautomycetin ( 5 )

Downstream Regulation
Effects of modification on WAVE1:
activity, inhibited ( 5 )

References 

1

Ceglia I, et al. (2017) WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine. Proc Natl Acad Sci U S A 114, 1395-1400
28115704   Curated Info

2

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

3

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

4

Odajima J, et al. (2011) Cyclin e constrains cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell 21, 655-68
21944720   Curated Info

5

Ceglia I, Kim Y, Nairn AC, Greengard P (2010) Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization. J Neurochem 114, 182-90
20403076   Curated Info

6

Wiƛniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info