Ser384
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Home > Phosphorylation Site Page: > Ser384  -  E2F4 (human)

Site Information
FAPLLRLsPPPGDHD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4763386

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 ) , mass spectrometry ( 1 , 2 , 4 ) , mutation of modification site ( 3 )
Disease tissue studied:
luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , colon ( 3 ) , epithelial ( 3 ) , HEK293T (epithelial) ( 3 ) , intestinal ( 3 ) , liver ( 2 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 3 )
Kinases, in vitro:
ERK1 (human) ( 3 )
Treatments:
EGF ( 3 ) , LPA ( 3 ) , SB216763 ( 3 ) , serum ( 3 ) , U0126 ( 3 )

Downstream Regulation
Effects of modification on E2F4:
intracellular localization ( 3 )
Effects of modification on biological processes:
cell cycle regulation ( 3 ) , transcription, induced ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
colorectal cancer ( 3 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

3

Paquin MC, et al. (2013) ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells. BMC Cell Biol 14, 33
23919615   Curated Info

4

Litovchick L, et al. (2011) DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev 25, 801-13
21498570   Curated Info