Ser59
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Home > Phosphorylation Site Page: > Ser59  -  HDAC6 (mouse)

Site Information
KGKMKKLsQPAEEDL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4759169

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 5 , 6 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 5 ) , 293 (epithelial) ( 1 ) , HeLa (cervical) ( 6 ) , MC3T3-E1 (preosteoblast) ( 3 ) , sertoli ( 1 )

Upstream Regulation
Putative in vivo kinases:
PIK3C3 (human) ( 1 )
Treatments:
insulin ( 5 ) , PTH(1-34) ( 3 )

Downstream Regulation
Effects of modification on HDAC6:
protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )

References 

1

Wang K, et al. (2023) Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin). Autophagy, 1-24
37450577   Curated Info

2

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

3

Williams GR, et al. (2016) Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods 92, 36-50
26160508   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

6

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

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