Ser82

Site Information
TGstGsCsVGAKASt SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4756303

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 )
Disease tissue studied:	melanoma skin cancer ( 2 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 3 ) , MCF-7 (breast cell) ( 1 ) , WM239A (melanocyte) ( 2 )

Upstream Regulation
Treatments:	selumetinib ( 2 ) , vemurafenib ( 2 )

References
1	Sacco F, et al. (2016) Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State. Cell Syst 2, 159-71 27135362 Curated Info
2	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
3	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info