Ser886
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Home > Phosphorylation Site Page: > Ser886  -  TOPBP1 (human)

Site Information
sRNAVALsAsPQLKE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4742697

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 4 )
Disease tissue studied:
cervical cancer ( 4 ) , cervical adenocarcinoma ( 4 ) , lung cancer ( 2 ) , non-small cell lung cancer ( 2 )
Relevant cell line - cell type - tissue:
H2077 (pulmonary) ( 2 ) , H322M (pulmonary) ( 2 ) , HCC1359 (pulmonary) ( 2 ) , HCC4006 (pulmonary) ( 2 ) , HeLa (cervical) ( 1 ) , HeLa S3 (cervical) ( 4 )

Upstream Regulation
Treatments:
nocodazole ( 4 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

4

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info