Ser181

Site Information
ATAAPPCsPLLKAPs SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4740876

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 )
Disease tissue studied:	breast cancer, triple negative ( 1 ) , leukemia ( 4 ) , acute myelogenous leukemia ( 4 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 3 , 4 ) , acute megakaryoblastic leukemia (M7) ( 3 ) , acute monoblastic leukemia (M5a) or acute monocytic leukemia (M5b) ( 3 ) , acute myeloblastic leukemia, with granulocytic maturation (M2) ( 3 ) , acute myeloblastic leukemia, without maturation (M1) ( 3 ) , B cell lymphoma ( 3 ) , non-Hodgkin's lymphoma ( 3 ) , multiple myeloma ( 3 )
Relevant cell line - cell type - tissue:	AML-193 (monocyte) ( 3 , 4 ) , breast ( 1 ) , CMK (megakaryoblast) ( 3 ) , CTS (myeloid) ( 3 ) , DOHH2 ('B lymphocyte, precursor') ( 3 ) , HEL (erythroid) ( 3 , 4 ) , Jurkat (T lymphocyte) ( 2 , 6 , 7 ) , Kasumi-1 (myeloid) ( 3 ) , KG-1 (myeloid) ( 3 ) , MV4-11 (macrophage) ( 3 , 4 ) , OPM-2 (plasma cell) ( 3 ) , P31/FUJ (erythroid) ( 3 , 4 ) , RL ('B lymphocyte, precursor') ( 3 ) , RPMI-8266 (plasma cell) ( 3 ) , SU-DHL-6 (B lymphocyte) ( 3 ) , T lymphocyte-blood ( 5 ) , U266 (plasma cell) ( 3 )

Upstream Regulation
Treatments:	antibody ( 5 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
3	Casado P, et al. (2013) Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors. Genome Biol 14, R37 23628362 Curated Info
4	Alcolea MP, et al. (2012) Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance. Mol Cell Proteomics 11, 453-66 22547687 Curated Info
5	Ruperez P, Gago-Martinez A, Burlingame AL, Oses-Prieto JA (2012) Quantitative phosphoproteomic analysis reveals a role for serine and threonine kinases in the cytoskeletal reorganization in early T cell receptor activation in human primary T cells. Mol Cell Proteomics 11, 171-86 22499768 Curated Info
6	Guo A (2011) CST Curation Set: 11732; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Curated Info
7	Guo A (2011) CST Curation Set: 11734; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Curated Info