Ser265
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser265  -  HDAC4 (human)

Site Information
QKVAERRssPLLRRK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4737971

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 6 ) , mass spectrometry ( 1 , 2 , 4 , 5 , 7 , 9 , 10 , 11 , 12 , 13 , 14 ) , mutation of modification site ( 2 , 3 , 6 , 10 ) , phospho-antibody ( 6 ) , western blotting ( 2 , 6 , 10 )
Disease tissue studied:
cervical cancer ( 14 ) , cervical adenocarcinoma ( 14 ) , leukemia ( 2 ) , chronic myelogenous leukemia ( 2 ) , pancreatic ductal adenocarcinoma ( 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 2 , 6 )
Kinases, in vitro:
PKACA (human) ( 2 )
Treatments:
angiotensin_2 ( 13 ) , cAMP_analog ( 2 , 6 ) , H-89 ( 2 ) , hesperadin ( 10 ) , isoproterenol ( 6 ) , N6-benzoyl-cAMP ( 6 ) , NKH_477 ( 2 ) , nocodazole ( 14 ) , propranolol ( 6 ) , Rp-cAMPS ( 6 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on HDAC4:
activity, induced ( 2 ) , intracellular localization ( 3 , 6 )
Effects of modification on biological processes:
transcription, inhibited ( 2 , 6 )

References 

1

Bouhaddou M, et al. (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell 182
32645325   Curated Info

2

Doddi SK, Kummari G, M V J, Kalle AM (2019) Protein kinase A-mediated novel Serine 584 phosphorylation of HDAC4. Biochem Cell Biol
30661366   Curated Info

3

Gomis-Coloma C, et al. (2018) Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells. J Cell Biol
29472387   Curated Info

4

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

5

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

6

Liu Y, Schneider MF (2013) Opposing HDAC4 nuclear fluxes due to phosphorylation by β-adrenergic activated protein kinase A or by activity or Epac activated CaMKII in skeletal muscle fibres. J Physiol 591, 3605-23
23652597   Curated Info

7

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

8

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

9

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

10

Guise AJ, et al. (2012) Aurora B-dependent regulation of class IIa histone deacetylases by mitotic nuclear localization signal phosphorylation. Mol Cell Proteomics 11, 1220-9
22865920   Curated Info

11

Grosstessner-Hain K, et al. (2011) Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Mol Cell Proteomics 10, M111.008540
21857030   Curated Info

12

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

13

Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53
20363803   Curated Info

14

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info