Ser1935
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.1.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser1935  -  MYH10 (human)

Site Information
LRrGGPIsFsssrSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4730818

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 11 ) , mutation of modification site ( 1 , 3 )
Disease tissue studied:
bone cancer ( 3 ) , breast cancer ( 4 , 9 ) , breast ductal carcinoma ( 4 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 ) , cervical cancer ( 11 ) , cervical adenocarcinoma ( 11 ) , leukemia ( 1 ) , T cell leukemia ( 1 ) , lung cancer ( 6 ) , non-small cell lung adenocarcinoma ( 6 ) , ovarian cancer ( 4 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 1 ) , breast ( 2 , 4 ) , BT-20 (breast cell) ( 9 ) , CHO (fibroblast) ( 3 ) , HeLa (cervical) ( 1 , 8 ) , HeLa S3 (cervical) ( 11 ) , Jurkat (T lymphocyte) ( 1 , 7 ) , K562 (erythroid) ( 8 ) , liver ( 5 ) , lung ( 6 ) , MDA-MB-468 (breast cell) ( 9 ) , ovary ( 4 ) , U2OS (bone cell) ( 3 )

Upstream Regulation
Putative in vivo kinases:
PKCZ (human) ( 1 )
Treatments:
ischemia ( 4 ) , nocodazole ( 11 ) , t-ACPD ( 1 )

Downstream Regulation
Effects of modification on MYH10:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 , 3 )
Induce interaction with:
ACTA1 (human) ( 1 ) , MYH10 (human) ( 1 )

References 

1

Schiffhauer ES, et al. (2019) Myosin IIB assembly state determines its mechanosensitive dynamics. J Cell Biol
30655296   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Juanes-Garcia A, et al. (2015) A regulatory motif in nonmuscle myosin II-B regulates its role in migratory front-back polarity. J Cell Biol 209, 23-32
25869664   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

6

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

7

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

8

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

9

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

10

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

11

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.