Ser346
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Home > Phosphorylation Site Page: > Ser346  -  PACSIN1 (human)

Site Information
SQAGDRGsVssYDRG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4730476

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , HEK293T (epithelial) ( 1 ) , neuron-'brain, hippocampus' ( 1 )

Upstream Regulation
Putative in vivo kinases:
PAK6 (human) ( 2 )

Downstream Regulation
Effects of modification on PACSIN1:
molecular association, regulation ( 1 )
Inhibit interaction with:
PICK1 (human) ( 1 )

References 

1

Anggono V, et al. (2013) PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proc Natl Acad Sci U S A 110, 13976-81
23918399   Curated Info

2

Gao J, et al. (2013) Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6. PLoS One 8, e77818
24204982   Curated Info

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