Thr43
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Home > Phosphorylation Site Page: > Thr43  -  DLK (mouse)

Site Information
CTPEKDLtPTQCVLR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4727854

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 , 5 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 2 ) , brain ( 3 , 4 , 5 ) , HEK293T (epithelial) ( 1 ) , neuron-dorsal root ganglia ( 1 ) , retinal ganglion ( 1 )

Upstream Regulation
Putative in vivo kinases:
JNK2 (mouse) ( 1 ) , JNK3 (mouse) ( 1 )
Kinases, in vitro:
JNK2 (mouse) ( 1 ) , JNK3 (mouse) ( 1 )
Treatments:
JNK_inhibitor_VIII ( 1 ) , NGF_withdrawal ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on DLK:
protein stabilization ( 1 )

References 

1

Huntwork-Rodriguez S, et al. (2013) JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. J Cell Biol 202, 747-63
23979718   Curated Info

2

Schindler J, Ye J, Jensen ON, Nothwang HG (2013) Monitoring the native phosphorylation state of plasma membrane proteins from a single mouse cerebellum. J Neurosci Methods 213, 153-64
23246975   Curated Info

3

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

4

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

5

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info