Ser62
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Home > Phosphorylation Site Page: > Ser62  -  Myc (mouse)

Site Information
LLPtPPLsPsRRsGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448586

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 3 , 4 , 5 , 7 , 8 , 9 , 10 , 11 ) , mutation of modification site ( 2 , 3 , 15 , 16 ) , phospho-antibody ( 2 , 12 , 13 , 15 , 16 ) , western blotting ( 2 , 12 , 13 , 16 )
Disease tissue studied:
anthrax infection ( 10 ) , colorectal cancer ( 13 ) , colorectal carcinoma ( 13 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 4 ) , 293 (epithelial) ( 12 ) , BJ (fibroblast) [NBS1 (human)] ( 15 ) , HCT116 (intestinal) ( 13 ) , heart ( 12 ) , HEK293-A (epithelial) ( 15 ) , HeLa (cervical) ( 2 ) , intestine ( 2 ) , JB6 CI41 (epidermal) ( 16 ) , lung ( 11 ) , macrophage-peritoneum ( 7 ) , MEF (fibroblast) [IGF1R (mouse)] ( 15 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 8 ) , myocyte-heart ( 12 ) , RAW 264.7 (macrophage) ( 5 ) , REF52 (fibroblast) ( 15 ) , spleen ( 10 , 11 ) , T lymphocyte-spleen ( 3 , 9 )

Upstream Regulation
Regulatory protein:
ERK2 (rat) ( 12 ) , P38A (mouse) ( 16 ) , PKCE (mouse) ( 14 )
Phosphatases, in vitro:
PPP2CA (human) ( 15 )
Treatments:
EGF ( 16 ) , IL-2 ( 3 ) , IL-33 ( 5 ) , okadaic_acid ( 15 ) , serum ( 15 ) , UV ( 14 )

Downstream Regulation
Effects of modification on Myc:
molecular association, regulation ( 15 ) , phosphorylation ( 15 ) , protein stabilization ( 15 )
Effects of modification on biological processes:
transcription, altered ( 15 )
Induce interaction with:
PIN1 (mouse) ( 15 )

References 

1

Gu J, et al. (2021) Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIγ/c-Myc/CDK6 signaling pathway. BMC Complement Med Ther 21, 163
34088288   Curated Info

2

Myant K, et al. (2015) Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation. Cell Rep 12, 1019-31
26235622   Curated Info

3

Preston GC, et al. (2015) Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J 34, 2008-24
26136212   Curated Info

4

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

5

Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44
25367039   Curated Info

6

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

7

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

8

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

9

Navarro MN, et al. (2011) Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat Immunol 12, 352-61
21399638   Curated Info

10

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

11

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

12

Lorenz K, Schmitt JP, Schmitteckert EM, Lohse MJ (2009) A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nat Med 15, 75-83
19060905   Curated Info

13

Zhang Y, Wang Z, Li X, Magnuson NS (2008) Pim kinase-dependent inhibition of c-Myc degradation. Oncogene 27, 4809-19
18438430   Curated Info

14

Aziz MH, Manoharan HT, Verma AK (2007) Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. Cancer Res 67, 1385-94
17283176   Curated Info

15

Yeh E, et al. (2004) A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol 6, 308-18
15048125   Curated Info

16

He Z, et al. (2003) p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factor. J Biol Chem 278, 26435-42
12748197   Curated Info

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