Ser2631
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Home > Phosphorylation Site Page: > Ser2631  -  TRIO (human)

Site Information
GtLKKSTsWHtALRL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4715630

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 5 , 6 , 7 )
Disease tissue studied:
lung cancer ( 6 ) , non-small cell lung cancer ( 6 )
Relevant cell line - cell type - tissue:
H2009 (pulmonary) ( 6 ) , H2887 (pulmonary) ( 6 ) , HCC1359 (pulmonary) ( 6 ) , HCC2279 (pulmonary) ( 6 ) , HCC4006 (pulmonary) ( 6 ) , HeLa (cervical) ( 5 , 7 ) , HOP62 (pulmonary) ( 6 ) , Jurkat (T lymphocyte) ( 3 ) , MEF (fibroblast) ( 1 ) , NCI-H2172 (pulmonary) ( 6 ) , NCI-H322 (pulmonary) ( 6 ) , Vero E6-S ('epithelial, kidney') ( 2 )

Upstream Regulation
Treatments:
CCCP ( 1 ) , Go_6976 ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )

References 

1

Fung TS, et al. (2022) Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria. Curr Biol 32, 1577-1592.e8
35290799   Curated Info

2

Bouhaddou M, et al. (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell 182
32645325   Curated Info

3

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

4

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

5

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

6

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

7

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

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